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Our patient began to experience nausea, abdominal cramping, and explosive. Along with its needed effects, glipizide / metformin may cause some unwanted effects. Metformin is the most common drug used and is the first-line agent in type 2 diabetes management. Metformin also has several non-FDA-approved indications, including gestational diabetes, management of antipsychotic-induced weight gain, type 2 diabetes prevention. However, gastrointestinal side effects are common, occurring in up to 75% of those who take metformin Side effects requiring immediate medical attention. However, gastrointestinal side effects are common, occurring in up to 75% of those who take metformin Also, exercise regularly and test for sugar in your blood or urine as directed. Call your doctor or contact 111 if you:. Metformin, FDA-approved in 1994, is an antidiabetic agent used in type 2 diabetes mellitus. Many people can control type 2 diabetes with diet and exercise Advertisement - Continue Reading Below. Metformin comes in both immediate-release and extended-release and is used in several combination products with other antidiabetic agents. Metformin can cause indigestion problems and can thus cause metformin diarrhoea. Metformin does not cause weight gain, unlike some other diabetes medicines. Some of the metformin’s most common side effects are as follows: Continuous feeling to vomit i. You'll need to have a medical exemption certificate Other side effects. Though extremely rare, you may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Having stomach ache Fever or chills Sleepiness Having unusual muscular pain. Although not all of these side effects may occur, if they do occur they may need medical attention. In some people, metformin leads to poor absorption of vitamin B12. The current labeling strongly recommends against use of metformin in some patients whose kidneys do not work normally.. Taste impairment weight loss headache nausea vomiting gas diarrhea abdominal bloating INFREQUENT side effects If experienced, these tend to have a Severe expression i trouble breathing If. Vitamin B12 deficiency is also a common side effect of taking metformin in higher doses or for long periods. “It varies from person to person, but up to 40 to 50 percent of people who use. Common Drug Side Effects The adverse effects of over-the-counter medications and prescription drugs can be mild, moderate, or severe. Vitamin B12 deficiency Taking metformin can cause vitamin B12 deficiency. Side effects requiring immediate medical attention. In some extreme cases, they can be life-threatening Common side effects aren't as likely as they might sound. It is also considered one of the safest pharmacological agents for the treatment of the disease. If you have diabetes, you can get free prescriptions for all of your medicines, not just your diabetes ones. For example, if a headache is listed as a commonly occurring side effect, this actually means that if 100 people take that medicine,. These side effects may include diarrhea, nausea, vomiting, abdominal discomfort, and/or flatulence, with severity ranging from mild to severe. Check with your doctor immediately if any of the following side effects occur while taking glipizide. That can lead to a vitamin B12 deficiency, though this only occurs after long-term medication use. Gastrointestinal adverse effects such as abdominal pain, nausea, dyspepsia, anorexia, and diarrhea are common and widely accepted when occurring at the start of metformin therapy. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired. Swallow the tablet or extended-release tablet whole with a full glass of water Advertisement - Continue Reading Below. Bloating, gastritis, and heartburn issues. Stomach trouble is the most common metformin side effect. Food and Drug Administration (FDA) is requiring labeling changes regarding the recommendations for metformin-containing medicines for diabetes to expand metformin's use in certain patients with reduced kidney function. Metformin is most notorious for causing a wide array of stomach issues. Diarrhea occurring long after the dosage titration period is much less well recognized. Feeling sick (nausea) Being sick (vomiting) Diarrhoea Stomach ache Loss of appetite A metallic taste in the mouth If this advice does not help and any of these side effects continue to bother you, tell your doctor or pharmacist. Metformin should be taken with meals to help reduce stomach or bowel side effects that may occur during the first few weeks of treatment. The most common side effects of metformin include: heartburn stomach pain nausea or vomiting bloating gas diarrhea constipation weight loss headache unpleasant metallic taste in mouth Nausea,.