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Ondansetron and promethazine are used to prevent nausea and vomiting. 67% of reviewers reported a positive effect, while 24% reported a negative effect Baseline nausea, anxiety, and sedation scores were similar. Promethazine is also used as an antihistamine and sedative. Brand names for promethazine include Phenergan, Phenadoz, and Promethegan. 2 out of 10 from a total of 135 ratings on Drugs. 72% of reviewers reported a positive effect, while 19% reported a negative effect. Prescribed for Light Sedation, Allergic Reactions, Allergic Rhinitis, Anaphylaxis, Motion Sickness more Prescription only. The reduction in anxiety was similar (ondansetron -13 mm, promethazine -14 mm; difference -1 mm; 95% CI = -10 to 10 mm) Zofran is really great for severe nausea and vomiting — chemotherapy, for instance. Zofran (ondansetron) works well to prevent nausea and vomiting. Phenergan has an average rating of 7. Ondansetron and promethazine reduced nausea similarly (ondansetron -34 mm, promethazine -36 mm; difference -2 mm; 95% CI = -13 to 8 mm). Evidence shows that the outcome at 30 minutes after administration the outcome between zofran and phenergan are equal for relief of nausea. Phenergan makes me very tired and out of it, but from what I read Zofran is mostly just for cancer/chemo patients. While it is safe for the general population, it is so effective, that it is also used in patients undergoing chemotherapy. Zofran, phernegan, reglan (metoclopramide) & their relations=anaphylaxis. Zofran is available as tablets, dissolvable tablets, strips, or liquid. 05) Zofran (ondansetron) Prescription only Promethazine may be used to relieve allergy symptoms and nausea. It's available in different forms that you don't have to swallow in case you can't keep anything down. Patients take one 8 mg tablet 30 minutes before the beginning of treatment, then every 12 hours for 1 to 2 days afterward.. Is promethazine more effective than Zofran? The older drug, promethazine, has antihistamine and sedating properties Dose of Zofran for Nausea 4-8 mg It is taken by mouth every 6 hours, as needed While it is safe for the general population, it is so effective, that it is also used in patients undergoing chemotherapy. Prescribed for Nausea/Vomiting, Nausea/Vomiting - Chemotherapy Induced more Prescription only Phenergan may be used to relieve allergy symptoms, nausea, or as a sleeping aid. Sedation is the main side effect What is the best medicine for nausea/vomitting -- Zofran, Reglan or Phenergan? Zofran does not show a serious side effect; on the other hand, Phenergan shows serious side effects. The older drug, promethazine, has antihistamine and sedating properties Nausea was reduced more significantly in the ondansetron-treated group (P < 0. Zofran is really great for severe nausea and vomiting — chemotherapy, for instance. Sedation is the main side effect. 7 out of 10 from a total of 448 ratings on Drugs. The reduction in anxiety was similar (ondansetron -13 mm, promethazine -14 mm; difference -1 mm; 95% CI = -10 to 10 mm) Any nausea med rec to take to my gi? Baseline nausea, anxiety, and sedation scores were similar. Zofran is an antiemetic (anti-nausea and vomiting) and selective 5-HT3 receptor antagonist and Phenergan is an antihistamine. Heidi Fowler answered Psychiatry 26 years experience Drink it strong: Ginger can reduce nausea & upset stomach One of the most effective anti-nausea medications is Zofran (ondansetron) which was developed to solve this problem. Side effects of Zofran and Phenergan that are similar include dizziness, drowsiness, constipation, and blurred vision. Zofran (ondansetron) Prescription only Phenergan (Promethazine) Prescription only Helps prevent nausea and vomiting. When I had appendicitis and was vomiting every couple of hours and anytime I tried to drink anything, I was grateful for Zofran. I have nausea/vomitting almost immediately after eating. No significant differences were seen in the blood pressures between groups (P > 0. For prophylactic administration zofran has better numbers. 6 / 5 average rating with 366 reviews forZofran Upsides Available in generic Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. Conclusion The main conclusion of the above discussion is that Zofran and Phenergan belong to different drug groups, but they are used to treat nausea and vomiting. FWIW, she has cyclic vomiting syndrome with migraines from dysautonomia. Brand names for ondansetron include Zofran, Zofran ODT, and Zuplenz. 6 / 5 average rating with 366 reviews forZofran. Zofran has safer side effect profile Ondansetron has an average rating of 7. There were more side-effects seen in the promethazine-treated when compared to the group with ondansetron treatment (P < 0. Comparing Phenergan vs Zofran Phenergan (promethazine) Zofran (ondansetron) Prescription only Phenergan may be used to relieve allergy symptoms, nausea, or as a sleeping aid. Prescribed for Light Sedation, Allergic Reactions, Allergic Rhinitis, Anaphylaxis more Prescription only. I''m not exactly sure how Reglan works. 4 / 5 average rating with 38 reviews forPhenergan Helps prevent nausea and vomiting.